摘要
目的观察月华胶囊对耐多药结核鼠T淋巴细胞亚群、TH1/TH2细胞因子的影响及其机理。方法将耐多药结核鼠随机分成模型组、月华胶囊组、抗结核药(OEZD)组、月华胶囊+抗结核药组,另设正常组。测各组中的CD4、CD8、CD4/CD8、IFN-γ、IL-2、IL-10、TNF-α。结果①与模型组比较,月华胶囊组、抗结核药组、月华胶囊+抗结核药组均明显减少CD4、CD4/CD8、INF-γ、IL-2降低(P<0.01),明显改善IL-10、INF-α升高(P<0.05);②与抗结核药组比较,月华胶囊+抗结核药组各指标差异均有显著性(P<0.05)。结论月华胶囊对耐多药结核鼠有治疗作用,其机理是通过调控T淋巴细胞亚群CD4、CD4/CD8及其TH1型细胞因子IFN-γ、IL-2,TH2型细胞因子IL-10和TNF-α的水平而实现的。
Objective：To observe the possible influence of YUEHUA capsule（YHC） on T Lymphocyte subgroup and TH1/TH2 cytokines in rats with Multi-drug resistant tuberculosis （MDR-TB） and its mechanism for this effeci. Methods：The experimental rats,as the studying model, were Divided into the modeling group, YHC group, the drug of antituberculosis （OEZD） group and YHC ＆ OEZD group in random process. And there was normal group. Then CD4^＋ , CD8^＋ , CD4 ^＋/CD8^＋ , IFN-γ, IL-2, IL-10, and TNF-α were observed in the all group. Result：Compared with the modeling group, CD^4＋ , CD4^＋/CDg^＋, IFN-γ and IL-2 were significantly controlled to go down（ P 〈 0.01 ）, and IL-10, INF-αwere significantly controlled to go up （ P 〈 0.05） in YHC group,OEZD group and YHC ＆ OEZD group. Compared with OEZD group, in YHC ＆ OEZD group the findings were significantly different（ P 〈 0.05）. Conclusion： YHC holds therapeutic effects on rats with MDR-TB. These effects may be associated with the controlled Level of CD4^＋, CD4^＋/CD8^＋ and TH1/TH2 cytokines, including IFN-γ, IL-2 and IL-10,and TNF-α.
出处
《中国实验方剂学杂志》
CAS
2006年第9期28-31,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省自然科学基金资助项目(03JJY3041)
