摘要
综述近年来有关酸敏感离子通道在缺血性脑损伤中的作用研究,论及酸敏感离子通道在脑中的分布和作用、它的激活以及在缺血性脑损伤中的作用机制及与谷氨酸受体的协同作用。酸敏感离子通道是一类由胞外酸化所激活的阳离子通道,而缺血性脑损伤正是由其引起胞内Ca2+超载所致,因此抑制其激活可以对抗缺血性脑损伤,为神经系统缺血性损伤的保护及药物治疗研究提供了新思路。
The recent studies on effect of acid-sensing ion channels（ASICs） in ischemic brain injury were reviewed, including their distribution and effect in brain, activation, mechanism of action in ischemic brain injury and synergism with glutamic acid receptor. ASICs are ligand-gated cation channels activated by extracellular acidification, and the ischemic brain injury results from intracellular Ca^2＋ overload. Therefore, blockade of ASICs can antagonize isehemic brain injury, which offers a new approach to the prtection from ischemic injury of nervous system and medication research.
出处
《药学进展》
CAS
2006年第8期337-341,共5页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金资助项目(30572196)
关键词
酸敏感离子通道
缺血性脑损伤
组织酸化
激活
协同作用
Acid-sensing ion channels
Ischemic brain injury
Tissue acidification
Activation
Synergism
