摘要
[目的]探讨Iressa对人高转移肝癌模型LCI-D20血管形成的抑制作用。[方法]12只原位移植LCI-D20肿瘤裸鼠分为采用空白对照组(A组)及Iressa治疗组(B组),用药28d后处死裸鼠,测量肿瘤质量,检测肿瘤组织微血管密度(MVD)。[结果]对照组肿瘤负荷平均为2.01/g,MVD平均为39.57个/HP;治疗组平均肿瘤负荷及平均MVD为1.18g、14.10个/HP,与对照组比较差异有显著性(P<0.05)。[结论]Iressa有抑制肝癌血管形成及肿瘤生长的活性。
[Purpose] To explore the inhibitive effect of Iressa on angiogenesis of highly metastatic human hepatocellular carcinoma model of LCI-D20. [Methods l Twelve nude mouse via orthotopic implantation of LCI-D20 were randomized into two groups： control group （A group） and Iressa group （B group）. Tumor mass and microvessel density （MVD） were measured at the 28th-day of treatment. [Results] The mean tumor mass were 2.01g and 1.18g in A and B group respectively. The mean MVD were 39.57/HP and 14.10/HP in A and B group respectively. There was significant difference hetween two groups （P〈 0.05）. [Conclusion ] Iressa inhibits the growth of tumor and angiogenesis of hepatocellular carcinoma.
出处
《中国肿瘤》
CAS
2006年第10期691-694,共4页
China Cancer
