血浆组织因子水平与肺癌病理特征的关系

Relationship Between Plasma Tissue Factor and Pathological Features of Lung Cancer

[目的]探讨血浆组织因子(TF)水平与肺癌病理特征的关系。[方法]104例经病理确诊肺癌患者,36例肺部良性疾病患者和30例健康者,用酶联免疫吸附法(ELISA)检测血浆TF水平。[结果]肺癌组TF水平显著高于肺部良性疾病组和健康组(P<0.01)。非小细胞肺癌(NSCLC)各组间比较差异无显著性(P>0.05),小细胞肺癌(SCLC)组TF水平高于非小细胞肺癌组(P<0.01)。NSCLC临床TNM分期的Ⅲ期、Ⅳ期TF水平显著高于Ⅰ～Ⅱ期(P<0.05,P<0.01),Ⅳ期TF水平高于Ⅲ期(P<0.01)。SCLC临床TNM分期的Ⅳ期TF水平显著高于Ⅲ期(P<0.01)。[结论]血浆TF水平与肺癌的病理组织分型有关;肺癌组血浆TF水平随TNM分期增加而升高,提示检测血浆TF水平可作为判断肺癌预后的参考指标。

[Purpose] To investigate the relationship between tissue factor（TF） and pathological features of lung cancer. [Methods] The plasma TF levels were defected by enzymelinked immunosorbent assay （ELISA） method in 104 cases with lung cancer pathologically proved,36 cases with benign lung disease and 30 healthy controls. [Resuits]The plasma TF levels in patients with lung eancer were significantly higher than those in benign and controls（P〈0.01）. No significant difference was found among TF levels in subgroups of NSCLC （P〉0.05）. Higher TF level were detected in SCLC group than that in NSCLC group（P〈0.01）. The plasma TF levels were significantly higher in NSCLC cases stages Ⅲ, Ⅳ than those in cases stages Ⅰ and Ⅱ （P〈0.05,P〈0.01）. The plasma TF level was significantly higher in SCLC cases stages Ⅳ than that in cases stages re（P〈0.01）. [Conclusions] TF level is related to pathological types in lung cancer. The TF level in patients with lung cancer rises with TNM up staged. It may be served as prognostic marker for lung cancer.