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O^6-甲基鸟嘌呤-DNA甲基转移酶与肺癌

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摘要 O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)是细胞中一种重要的DNA直接修复酶,它在人类抵抗烷化剂所致损伤中发挥重要作用。随着人们对于MGMT与肺癌关系的认识不断加深,MGMT已成为肺癌研究中的一个重要方向。本文综述近年来关于MGMT研究的最新进展,包括MGMT的基因结构与功能,MGMT的分布及活性影响因素,MGMT与肺癌发生、诊断及治疗的关系。
作者 杨进 陆友金
出处 《国际呼吸杂志》 2006年第9期674-677,共4页 International Journal of Respiration
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