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细胞外基质与肺癌的细胞凋亡及耐药的关系 被引量:1

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摘要 肿瘤治疗过程中出现化疗耐药已经成为肿瘤治疗的一个瓶颈,目前对耐药机制研究较热的是细胞黏附介导的耐药(CAM-DR)。它是通过细胞黏附分子与细胞外基质黏附后产生的生物学效应。肿瘤生存的微环境富含细胞外基质及其受体整合素,他们对肿瘤生存抗细胞凋亡及耐药起着相当大的作用。肺癌是恶性肿瘤中致死率排第一位的,上述微环境的研究可能为肺癌治疗找到了新的契机。
作者 徐妍 周彩存
出处 《国际呼吸杂志》 2006年第9期678-680,共3页 International Journal of Respiration
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