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内原性抗菌肽CAP18/LL37的研究进展 被引量:4

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摘要 内原性抗菌肽CAP-18/LL37是发现的人类唯一的Cathelicidins家族的成员,是中性粒细胞特殊颗粒(亦称二级颗粒)中的主要蛋白质,其含有N-端Cathelin域及C-端抗菌活性域,而蛋白酶3是唯一在CAP18出胞后对其进行裂解的蛋白酶。经研究其有抗微生物活性、结合和抑制脂多糖活性、免疫调节、参与伤口的愈合和血管的发生等多种功能,本文就近年国外对其结构、代谢、功能等各方面研究做一综述。
出处 《国际呼吸杂志》 2006年第9期710-712,共3页 International Journal of Respiration
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参考文献14

  • 1Yang D,Chen Q,Albert P,et al.LL-37,the neutrophil granule and epithelial cell derived cathelicidin,utilizes formyl peptide Receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils,monocytes,and T cells.J Experimental Med,2000,192(7):1069-1074.
  • 2Scott MG,Davidson DJ,Gold MR,et al.The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses.J Immunol,2002,169(7):3883-3891.
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