军队结核病患者耐药状况分析

The Analysis of Drug Resistance in Military Patients with Pulmonary Tuberculosis

目的了解部队结核病患者的耐药状况,为防治提供依据。方法应用改良-罗氏培养基。采用绝对浓度间接法对1995年1月—2004年12月收治的586例军人结核病患者痰标本进行异烟肼、利福平、链霉素及乙胺丁醇四药的药敏实验。结果586例患者痰培养获得结核分枝杆菌79株,其中耐药菌株45株,耐药率57.0%(45/79)。耐1药率、耐2药率、耐3药率及耐多药率分别为31.6%,13.9%,2.5%及8.9%,分别占所有耐药患者的55.6%,24.4%,4.4%15.6%,以耐1药为主。利福平、异烟肼、乙胺丁醇及链霉素的耐药率分别为20.3%,21.5%,24.1%及30.4%。结论部队结核病患者耐药状况不容乐观,必须采取多种措施加强部队结核病控制工作。

Objective To evaluate the situation of ami-tuberculosis drug resistance in military patients with pulmonny tuberculosis and find out the scientific basis of tubereuloais control. Methods The sputom samples of 586 military patients with pulmonny tuberculoais hospitalized from Januny 2005 to December 2004 were cultured and tested for resistance to lsoniazid （ H ）, Rffampicin （R）, Ethamhutol （E） and Streptomycin （S） by the absolute concentration method. Results 79 strains of tubereulous＇mycohacterium were obtained, drug resistan strains were 45, the fate of drug resistance was 57.0% （45/79） . The rates of drug resistance to one-drug, to two-drug,to three-drug and to multi-dug were 31.6% , 13.9% ,2.5% and 8.9% respectively. The fates of drug resistance to R, H, E and S were 20.3% ,21.5% , 24.1 and 30.4% respectively. Conclusion The drup resistance of military patients with pulmonny tuberculosis was serious. Effective methods should be taken to control tuberculosis in the army.