精神分裂症患者失匹性负波(MMN)研究

STUDY ON MISMATCH NEGATIVITY OF PATIENT WITH SCHIZOPHRENIA

目的：了解首发精神分裂症患者失匹性负波（MMN）的特征以及治疗缓解后MMN的变化。方法：应用美国Bravo脑电生理仪，记录45例首发精神分裂症患者和40名健康人的MMN，同时记录P300电位比较，并用阳性和阴性症状量表（PANSS）评定患者精神症状。患者组于治疗5周和12周时进行MMN随访。结果：（1）与正常组比较，首发精神分裂症组的MMN潜伏期延迟和波幅降低（正常组199．7±29．9ms和7．8±3．8μV，患者组221．4±32．6ms，4．5±3．3μV，P均〈0．01），患者组P300中靶潜伏期P3同时延迟（P〈0．01）。（2）MMN潜伏期延长和波幅低，与PANSS阳性症状和思维障碍分呈负相关（P〈0．05～0．01）。（3）患者组经治疗12周后，MMN波幅呈增大改变和潜伏期缩短（P〈0．01），反映患者的认知功能改善。结论：MMN技术可反映首发精神分裂症患者诱发脑电的自动加工过程。MMN可作为精神分裂症患者的临床应用检测指标。

Objectives ：To investigate with first - episode schizophrenia and its variation characteristic of mismatch negativity （MMN ） in patitnts after treatment. Methods： MMN and P300 were recorded from 45 schizophrenics and 40 normal controls with American Brova instrument, and assessea their psychotic symptoms with PANSS. Results： Compared with NC, schizophrenics showed delayed MMN latency （NC： 199.7 ± 29.9ms, Sch ： 221.4 ± 32.6ms, P 〈 0. 01 ）, decreased MMN amplitude （ NC ： 7.8 ± 3.8 μV, Sch ： 4. 5 ±3.31μV, P 〈 0.01 ）, and delayed latency of P300 （ P 〈 0. 01 ）. Delayed MMN latency and decreased MMN amplitude correlated negatively with positive symptoms and thought disorder. After 12 weeks of treatment, abnormal MMN was improved with improving psychotic symptoms. Conclusions： MMN could reflect the automatic processing of schizophrenics, and might be useful markers applying into schizophrenics.