索他洛尔联合普罗帕酮治疗阵发性房颤的效果观察

Clinical efficacy of low-dose Sotalol combined with Propafenone in patients with paroxysmal atrial fibrillatien

目的观察索他洛尔联合普罗帕酮在房颤转复后维持窦律的临床疗效和安全性。方法阵发性心房颤动患者29例,分为两组。治疗组(Ⅰ组)13例,用索他洛尔转复房颤,恢复窦律后索他洛尔80mg/ d联合普罗帕酮300mg/d口服维持。对照组(Ⅱ组)16例,可达龙(即胺碘酮)转复房颤,恢复窦律后可达龙0．2g/d或0．2g/d、每周5d,口服维持。每周观察心率、Q—T间期、房颤发作次数、持续时间、药物不良反应,随访3个月。结果Ⅰ组、Ⅱ组治疗显效率分别为69．23%、80%；有效率分别为30．77%、20%；两组治疗效果无显著性差异(均P＞0．05)。治疗后两组窦性心率较治疗前减慢,差异显著(均P＜0．01),但组间无明显差异(P＞0．05)。治疗后两组Q—T间期较治疗前无显著性差异(均P＞0．05),组间亦无显著性差异(P＞0．05)。无其它不良反应。结论小剂量索他洛尔联合普罗帕酮在房颤转复后维持窦律方面,治疗效果好、安全性高、依从性强。

Objective To observe the clinical efficacy of low-dose sotalol combined with propafenone for paroxysmal atrial fibrillation（PAF）. Methods 29 patients with PAF were divided into two groups： Group Ⅰ, after sotalol treansformed PAF low-dose sotalol 80mg/d and propafenone 300mg/d maintained sinus rhythm; Gooup Ⅱ, after amiodarone treansformed PAF amiodarone 0.2g/d or 0.2g/d, five days in every week maintained.The treatment lasted for three months.Times of atrial fibrillation and lasting time, sinus heart rate,Q-T interval and adverse reactions were observed in every week.Results In group Ⅰ,group Ⅱ markedly effective rate were 69.23%,80% respectively;effective rate respectively were 30.77%,20%. There were no significant differences in the two groups （P〉0.05）.Before and after treatment between two groups there were significant differences in sinus heart rate （all,P〈0.01）.But there was no significant difference in sinus heart rate after the treatment between two groups（P〉0.05）.There all were no signifcant difference in Q-T interval before and after treatment between the two groups（all,P〉0.05）.Conclusion The clinical effects of low-dose sotalol combined with propafenone for PAF are better and relatively safe. The occurrence rates of adverse reaction are very low.