急性脑梗死患者血浆hsCRP、MMP9、IL-6含量的测定及临床意义

Evaluation of the plasma hsCRP、MMP9 and IL-6 levels in patients with acute cerebral infarction

目的探讨急性脑梗死患者血浆hsCRP、MMP9I、L-6水平与脑梗死面积及病情严重程度的关系。方法测定168例脑梗死患者及50例正常对照组血浆hsCRP、MMP9、IL-6水平,并分析其相互关系。结果(1)急性脑梗死组的血浆hsCRP、MMP9I、L-6水平均明显高于对照组;(2)大梗死组的血浆hsCRP、MMP9I、L-6水平均明显高与中、小梗死组;(3)有意识障碍的脑梗死患者的血浆炎性血清标志物hsCRP、MMP9I、L-6水平均明显高于无意识障碍者。结论炎性血清标志物hsCRP、MMP9I、L-6参与了脑梗死的发生发展过程,早期应用抗炎制剂治疗脑梗死可能具有潜在的临床价值。

Objective To investigate the clinical importance of the plasma hsCRP,MMP9 and IL-6 levelsin patients with acute cerebral infarction. Methods： 168 cases of acute cerebral infarction and 50 cases normal controls were tested for plasma hsCRP, MMPg, IL-6,and correlation was analyzed. Results： （1）The levels of the plasma hsCRP,MMP9 and IL-6 of patients with cerebral infarction were significantly higher than that in controls. （2）The levels of the plasma hsCRP,MMP9 and IL-6 in big cerebral infarction were significantly higher than those in middle and small cerebral infarction. （3） The levels of the plasma hsCRP, MMP9 and IL-6 of patients with mental disorder were significantly higher than those patients without mental disorder. Conclusion： Cerebral infarction is closely related to inflammatory marker： hsCRP, MMP9 and IL-6. It is important to use anti-inflammatory drugs in patients with cerebral infarction.