摘要
The presence of gene polymorphisms of the estrogen receptors ERα (PvuII and XbaI) and ERβ (AluI) in 61 women with endometriosis was investigated. A statistically significant correlation between PvuII ERα gene polymorphism (PvuII), both in homozygosity (PP) and in heterozygosity (Pp), and a recurrence of endometriosis was found. In conclusion, women affected by endometriosis with the ERα polymorphic allele, even if heterozygous, have a worse prognosis, and these results suggest that the ERα gene polymorphisms may be included among the genetic risk factors for endometriosis.
The presence of gene polymorphisms of the estrogen receptors ERα （PvuⅡ and XbaⅠ） and ERβ （AluⅠ） in 61 women with endometriosis was investigated. A statistically significant correlation between PvuII ERα gene polymorphism （PvuⅡ）, both in homozygosity （PP） and in heterozygosity （Pp）, and a recurrence of endometriosis was found. In conclusion, women affected by endometriosis with the ERα polymorphic allele, even if heterozygous,have a worse prognosis, and these results suggest that the ERα gene polymorphisms may be included among the genetic risk tactors tor endometriosis.
