摘要
Objective: To test the hypothesis that statins improve hyperandrogenemia in women with polycystic ovary syndrome (PCOS).Design: Prospective, randomized trial.Setting: Academic medical center.Patient(s): Forty- eight women with PCOS.Intervention(s): Subjects were randomized to a statin group (simvastatin, 20 mg daily plus oral contraceptive pill [OCP]; n = 24) or an OCP group (OCP alone; n = 24).Main Outcome Measure(s): Serum T.Result(s): Baseline parameters of both groups were comparable.After 12 weeks of treatment, serum T levels declined by 41% in the statin group and by 14% in the OCP group.In the statin group, there was a greater decrease of LH (43% decrease vs.9% in the OCP group) and a greater decline of LH/FSH ratio (44% vs.12% ).In the statin group, total cholesterol declined by 10% and low- density lipoprotein (LDL) by 24% .In the OCP group, total cholesterol increased by 8% , and LDL was unchanged.Conclusion(s): This is the first study demonstrating that statin decreases T levels and normalizes gonadotropin levels in women with PCOS.Statin therapy might offer a novel approach, providing endocrine and cardiovascular benefits.
Objective： To test the hypothesis that statins improve hyperandrogenemia in women with polycystic ovary syndrome （PCOS）. Design： Prospective, randomized triM. Setting： Academic medical center. Patient（s） ： Forty -eight women with PCOS. Intervention（s） ： Subjects were randomized to a statin group （simvastatin, 20 mg daily plus oral contraceptive pill [OCP] ;n = 24） or an OCP group （OCP alone; n = 24）. Main Outcome Measure（s） ：Serum T. Result（s）：Baseline parameters of both groups were comparable. After 12 weeks of treatment, serum T levels declined by 41% in the statin group and by 14% in the OCP group. In the statin group, there was a greater decrease of LH （43% decrease vs. 9% in the OCP group） and a greater decline of LH/ FSH ratio （44% vs. 12% ） . In the statin group, total cholesterol declined by 10% and low- density lipoprotein （LDL） by 24%. In the OCP group, total cholesterol increased by 8%, and LDL was unchanged. Conclusion（s）： This is the first study demonstrating that statin decreases T levels and normalizes gonadotropin levels in women with PCOS. Statin therapy might offer a novel approach, providing endocrine and cardiovascular benefits.
