摘要
Treatment of symptomatic oral lichen planus remains a challenging problem. This study compared the efficacy of topical tacrolimus ointment with triamcinolone acetonide ointment in patientswith oral lichen planus. Twenty patients (group I) were treatedwith topical tacrolimus 0.1% ointment 4 times daily, and 20 (group II) were treated with triamcinolone acetonide 0.1% ointment 4 times daily. The clinical effect was graded after 6 weeks. In group I, 6 patients healed, 12 showed improvement and 2 showed no improvement. In group II, 2 patients healed, 7 improved and 11 showed no improvement. The most commonly reported side-effect in both groups was temporary burning or stinging at the site of application. Unfortunately, oral lesions recurred within 3- 9 weeks of cessation of treatment in 13 of the 18 patients who had initially shown an improvement or were healed in group I and in 7 of the 9 patients in group II. Topical tacrolimus 0.1% ointment induced a better initial therapeutic response than triamcinolone acetonide 0.1% ointment. However, relapses occurred frequently within 3- 9 weeks of the cessation of treatment.
Treatment of symptomatic oral lichen planus remains a challenging problem. This study compared the efficacy of topical tacrolimus ointment with triamcinolone acetonide ointment in patientswith oral lichen planus. Twenty patients （group Ⅰ） were treatedwith topical tacrolimus 0. 1% ointment 4 times daily, and 20 （group Ⅱ） were treated with triamcinolone acetonide 0. 1% ointment 4 times daily. The clinical effect was graded after 6 weeks. In group Ⅰ, 6 patients healed, 12 showed improvement and 2 showed no improvement. In group Ⅱ, 2 patients healed, 7 improved and 11 showed no improvement. The most commonly reported side-effect in both groups was temporary burning or stinging at the site of application. Unfortunately, oral lesions recurred within 3 - 9 weeks of cessation of treatment in 13 of the 18 patients who had initially shown an improvement or were healed in group Ⅰ and in 7 of the 9 patients in group Ⅱ. Topical tacrolimus 0. 1% ointment induced a better initial therapeutic response than triamcinolone acetonide 0. 1% ointment. However, relapses occurred frequently, within 3- 9 weeks of the cessation of treatment.
