摘要
Background: Alopecia areata (AA) is a polygenic immunemediated disorder affecting the hair follicle for which an association with human leukocyte antigen HLA-DRB1 11 has been described. Objective: Two parameters including age of onset and extent of the disease (patchy AA and AT/AU forms)- were correlatedwith the presence or absence of HLA-DRB1 11 and its alleles in 88 severe AA patients. Methods: Patients and healthy controls were typed for HLA-DR and - DQ by molecular method. Results: Among AA patients, 37.5% (a proportion rising to 72% when taking patients who began their first patch before the age of 20 years) were positive for HLADRB1 11 compared to 21.2% healthy controls (p = 0.004, RR = 2.1). DRB1 11-positive status was associated with earlier development of the first AA patch, at the mean age of 16 years compared to 27 years (p = 0.003) in DRB1 11-negative patients. Among the DRB1 11 alleles, the presence of DRB1 1104was associated with the earliest occurrence of AA. Conclusion: Our data indicate that the HLA system largely through DRB1 1104 allele influences AA onset rather than extension considering patchy AA and AT/AU.
Background： Alopecia areata （AA） is a polygenic immunemediated disorder affecting the hair follicle for which an association with human leukocyte antigen HLA-DRB 1 ＊ 11 has been described. Objective： Two parameters including age of onset and extent of the disease （patchy AA and AT/AU forms） - were correlatedwith the presence or absence of HLA-DRB1 ＊ 11 and its alleles in 88 severe AA patients. Methods： Patients and healthy controls were typed for HLA-DR and -DQ by molecular method. Results： Among AA patients, 37.5% （a proportion rising to 72% when taking patients who began their first patch before the age of 20 years） were positive for HLADRB1 ＊ 11 compared to 21.2% healthy controls （p = 0. 004, RR = 2. 1 ） . DRB1 ＊ 11-positive status was associated with earlier development of the first AA patch, at the mean age of 16 years compared to 27 years （p = 0. 003） in DRB1 ＊ 11-negative patients. Among the DRB1 ＊ 11 alleles, the presence of DRB1 ＊ 110dwas associated with the earliest occurrence of AA. Conclusion： Our data indicate that the HLA system largely through DRB1 ＊ 1104 allele influences AA onset rather than extension considering patchy AA and AT/AU.
