表皮生长因子受体在人甲状腺癌的免疫定位

IMMUNOLOCALIZATION OF EPIDERMAL GROWTH FACTOR RECEPTOR IN HUMAN THYROID CARCINOMAS

应用免疫组织化学方法,研究表皮生长因子受体(EGF-R)在38例甲状腺瘤和甲状腺癌中的免疫定位.EGF-R的免疫反应大部分在瘤细胞或癌细胞的细胞膜上,部分在细胞质内.EGF-R阳性染色在甲状腺瘤中仅1/8(13%),染色较弱;在乳头状腺癌中为12/18(67%),滤泡型腺癌为7/12(58%),染色较强.提示EGF-R与甲状腺癌的形成密切相关.

Immunolocalization of epidermal growth factor receptor (EGF-R) was performed in 38 cases of human thyroid tumors, including papilloid adenoma, and papilloid ade-nocarcinoma and follicular adenocarcinoma. Most of the immunohistochemical staining of EGF-R protein were found to be associated with the diffuse cytoplasmic membrane of the cells and some in the cytoplasm. Positive staining was present in 63. 3% (19/30) of the malignant cases, but only in 12.5% (1/8) of the benign adenomas. The results suggest that expression of EGF-R may be involved in the neoplastic process of thyroid tissue.