摘要
灌注脑室以不同溶剂配制的肾上腺髓质素(AM),观察并比较它们对血糖及血糖调节激素的影响.结果表明:(1)中枢给以生理盐水配制的AM,可使血浆胰岛素、C 肽明显升高,胰升糖素、血糖浓度降低.(2)用30%葡萄糖配制AM与单纯灌注糖溶液相比,AM可使血浆胰岛素、C肽明显升高,胰升糖素明显降低,血糖浓度则无差异.说明AM参与中枢神经系统对胰岛分泌激素的调节.
After intracerebral ventricular administration of adrenomedullin (AM) in normal saline (NS) or 30% glucose to rats, the effects on blood glucose and glucose regulatory hormones were studied and compared. 1) Am in NS increased significantly the concentration of plasma insulin and C peptide, and decreased the concentration of glucagon and blood glucose. 2) As compared with 30% glucose alone, AM in 30% glucose raised significantly the plasma insulin and C peptide and decreased significantly the glucagon concentration, but the blood glucose level remained unchanged. The results showed that the AM plays a role in the regulation of pancreatic hormone secretion by central nerve system.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1996年第3期160-161,共2页
Chinese Journal of Endocrinology and Metabolism