短期和长期热量限制对大鼠胰岛素抗性的影响

EFFECT OF SHORT- AND LONG-TERM CALORIC RESTRICTION ON INSULIN RESISTANCE IN MALE FISHER-344 RATS

研究短期和长期热量限制（caloric restriction,CR）对大鼠胰岛素抗性的影响。结果显示:短期和长期CR鼠显著减轻其肝重、体重;血糖、胰岛素浓度显著低于自由进食（ad libitum,AL）鼠;胰岛素抵抗指数和敏感指数分别显著低于和高于对应的AL鼠。提示短期和长期CR鼠均能适应低浓度的葡萄糖与胰岛素环境,并有效地利用葡萄糖;胰岛素抗性随鼠龄增加而增高,此现象可通过CR而延缓;CR鼠可能由于体脂的减少、运动的增加而增加胰岛素敏感性、降低胰岛素抗性。CR可减轻大鼠的体重,降低血糖、胰岛素浓度,也增强胰岛素敏感性和降低胰岛素抗性。

The effect of short- and long-term caloric restriction (CR) on insulin resistance in male Fisher-344 rats was studied. The short- and long-term CR rats had not only significantly lower blood glucose and insulin levels, but also lower body and liver weights as compared with ad libitum (AL) rats. The insulin resistance index (IRI) was markedly lower, but the insulin sensitive index (ISI) was significantly higher in CR rats than in AL ones. The results indicate that CR rats can ultilize glucose and adapt themselves to the condition of lower insulin and glucose concentrations. They have higher ISI and lower IRI, which probably result from decreased body fat and increased exercise. Insulin resistance increased with aging, and this phenomenon could be retarted through CR. It is concluded that rats on CR show decreased body and liver weights, lowered glucose and insulin concentrations, lowered insulin resistance, and elevated insulin sensitivity.