晨尿尿蛋白/尿渗透压比值测定的临床应用评价

Evaluation of protein-osmolality ratio of morning urine samples for quantitative assessment of proteinuria

目的探讨晨尿尿蛋白/尿渗透压比值与24h尿蛋白定量的相关性。方法检测107例不同肾脏疾病患者的24h尿蛋白定量、晨尿尿蛋白/尿肌酐比值和尿蛋白/尿渗透压比值,并进行相关性分析。结果晨尿尿蛋白/尿渗透压比值与24h尿蛋白定量具有相关性(Y=1.14X+0.08;r=0.687,P<0.05);以尿蛋白/尿渗透压比值2.32作为临界值,本法的敏感性为94.7%,特异性为97.6%。结论晨尿尿蛋白/尿渗透压比值可替代24h尿蛋白定量广泛应用于临床。

Objective To evaluate the relationship between protein-osmolality ratio of morning urine and 24h urinary protein. Methods Urine samples of 107 patients with renal diseases were analyzed for 24h urinary protein,protein-osmolality ratio and protein-creatinine ratio. Results It was cornfirmed that there was a significantly positive correlation between the protein-osmolality ratio and the quantitation of 24 h urinary protein（ Y= 1.14X ＋0.08 ; r= 0. 687, P〈0. 05 ）. A protein-osmolality ratio of greater than 2.32 correlated with massive proteinuria（sensitivity 94.7 %, specificity 97.6% ）. Conclusion Protein-osmolality ratio of morning urine samples can be used reliably to assess the degree of proteinuria.