乙型肝炎病毒A1762T/G1764A变异的临床意义

The Clinical Significance of Hepatitis B Virus A1762T/G1764A Mutations .

目的探讨乙肝病毒(HBV)A1762T/G1764A变异的临床意义。方法应用基因芯片方法对115例慢性乙型肝炎患者进行HBVA1762T/G1764A变异检测,分析A1762T/G1764A变异与临床类型、HBV-DNA、HBeAg及肝纤维化血清学指标透明质酸(HA)、Ⅲ型前胶原(PⅢP)、Ⅳ型胶原(CL-Ⅳ)、层粘蛋白(LN)的关系。结果慢性乙型肝炎轻度、中度、重度及肝炎肝硬化中A1762T/G1764A变异率分别为43%、55%、61%、89%(P<0.05);A1762T/G1764A变异组病人肝纤维化指标HA、PⅢP、CL-Ⅳ明显高于对照组(P<0.05)。结论HBVA1762T/G1764A变异与与疾病进展及肝纤维化具有相关性。

Objective To explore the clinical significance of hepatitis B virus A1762T/G1764A mutations in patients with hepatitis B. Methods A1762T/G1764A mutations were detected in 115 patients with chronic hepatitis B by gene chip, and the relationships between the mutations and clinical type, HBV - DNA, hyaluronic acid （HA） , procollagen Ⅲ N - terminal peptide （ P Ⅲ P） , collagen type Ⅳ （ CL - Ⅳ ） , laminin（LN） , HBeAg were analyzed. Results The rates of A1762T/G1764A mutations in Mild, Median, Gravies type of chronic hepatitis B and liver cirrhosis group were 43% ,55% ,61% and 89% （P 〈0.05） , respectively. HA, PⅢP, and CL- Ⅳ levels in mutational group were significantly higher than that in control group（P 〈0.05）. Conclusions A1762T/G1764A mutations were closely related to progression of liver deterioration and fibrosis.