期刊文献+

胰岛素依赖型糖尿病起病年龄相关的HLA-DQA1遗传异质性 被引量:4

MAGNETIC RESONANCE ANGIOGRAPHY OF CEREBRAL INFARCTION AND CLINICAL ANALYSIS
下载PDF
导出
摘要 比较3组起病年龄不同的胰岛素依赖型糖尿病(IDDM)病人(A组≤14岁,B组15~30岁,C组≥31岁)其HLA-DQA1链52位精氨酸(Arg)与IDDM易感性之间的关系。结果显示,A组HLA-DQA1链52位Arg(+)等位基因频率为87.5%,明显高于对照组(53.9%,P<0.05,RR=5.98)及B组和C组(P<0.05);A组HLA-DQA1链52Arg(+)/Arg(+)表现型的频率为75%,明显高于C组(23.1%,P<0.05)。本文提示:HLA-DQA1链52位Arg与IDDM易感性之间的关系存在着起病年龄相关的异质性,有必要进一步研究以阐明IDDM的免疫遗传学本质。 0 cases of cerebrovasular morphology in acute stage of cerebral infarction were observed by MRA.63 cases (78.8%)were abnormal and could be divided into four types:①total occlusion;②partial occlusion;③sparse image and slow blood flow;④diffuse blood vessels tenuity and rigidity.Type ① and type ② were the commonest,account for 42.0% and 30.2% respectively.The size of the lesion was correlative to the degree of occlusion.MRA was done again in 18 cases after therapy for 21 ̄28 days.In 9 cases of type ①,5 of massive cerebral infarction with total occlusion revealed recirculation and bleeding lesions.The other 4 cases did not show any changes in vessel figures but had lateral circulation and the lesions become smaller.Application of vasodilators may promote the establishment of lateral circulation for non massive cerebral infarction and then be helpful to improve the blood supply of the lesion.
出处 《中山医科大学学报》 CSCD 1996年第3期205-209,共5页 Academic Journal of Sun Yat-sen University of Medical Sciences
基金 广东省科委重点攻关项目基金
关键词 糖尿病 Ⅱ型 遗传学 HLA-DQ 抗原 异质性 cerebral infarction/pathology cerebral infarction/radionuclide imaging magnetic resonance angiography
  • 相关文献

参考文献2

  • 1颜纯,中国糖尿病杂志,1994年,2卷,1期,3页
  • 2王--,中华内分泌代谢杂志,1993年,9卷,4期,202页

同被引文献10

  • 1扬骁,王姮,向红丁.139例胰岛素依赖型糖尿病发病方式的分析[J].中华内科杂志,1994,33(1):37-39. 被引量:2
  • 2张胜兰 唐天华 等.胰岛素依赖型糖尿病与病毒抗体[J].中华医学杂志,1992,(72):174-174.
  • 3[3]Banatvala JE Bryant J, Schern thamer G (1985). Coxsackie B.Mumps rubella and cytomegalovirus specific IgM responses in patients with junvenile onset insulindependent diabetes mellitus in britain austria and australia. Lancet, 1992, 1:1409
  • 4杨晓,中华内科杂志,1994年,33卷,1期,37页
  • 5张胜兰,中华医学杂志,1992年,72卷,3期,174页
  • 6孙逸平,高小江,秋季南,李慧真,谭毓绘,徐林敏,郭玉红,沈晶晶,P.Stastny,SW.Serjeanson.中国人南北群体的HLA class Ⅱ基因的变异性[J]中国免疫学杂志,1992(05).
  • 7邸国勋,叶伸波,富朴云,齐今吾,宋芳吉,徐沈育,李惠刚,井村裕夫,葛谷英嗣,清野裕.东北地区汉族胰岛素依赖型糖尿病HLA抗原类型分布调查[J]中国医科大学学报,1987(05).
  • 8范丽安,徐静娟,丁惠娟,费虹明,许曼音,张达青,蔡厚明.HLA和胰岛素依赖型糖尿病[J]上海免疫学杂志,1983(03).
  • 9Steven G. E. Marsh,Julia G. Bodmer. HLA class II nucleotide sequences, 1991[J] 1991,Immunogenetics(5-6):321~334
  • 10Dr. L. Groop,P. -H. Groop,S. Koskimies. Treatment failures in patients with Type 2 (non-insulin-dependent) diabetes[J] 1988,Diabetologia(3):186~187

引证文献4

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部