胰岛素依赖型糖尿病起病年龄相关的HLA－DQA1遗传异质性

MAGNETIC RESONANCE ANGIOGRAPHY OF CEREBRAL INFARCTION AND CLINICAL ANALYSIS

比较３组起病年龄不同的胰岛素依赖型糖尿病（ＩＤＤＭ）病人（Ａ组≤１４岁，Ｂ组１５～３０岁，Ｃ组≥３１岁）其ＨＬＡ－ＤＱＡ１链５２位精氨酸（Ａｒｇ）与ＩＤＤＭ易感性之间的关系。结果显示，Ａ组ＨＬＡ－ＤＱＡ１链５２位Ａｒｇ（＋）等位基因频率为８７．５％，明显高于对照组（５３．９％，Ｐ＜０．０５，ＲＲ＝５．９８）及Ｂ组和Ｃ组（Ｐ＜０．０５）；Ａ组ＨＬＡ－ＤＱＡ１链５２Ａｒｇ（＋）／Ａｒｇ（＋）表现型的频率为７５％，明显高于Ｃ组（２３．１％，Ｐ＜０．０５）。本文提示：ＨＬＡ－ＤＱＡ１链５２位Ａｒｇ与ＩＤＤＭ易感性之间的关系存在着起病年龄相关的异质性，有必要进一步研究以阐明ＩＤＤＭ的免疫遗传学本质。

0 cases of cerebrovasular morphology in acute stage of cerebral infarction were observed by MRA.63 cases (78.8%)were abnormal and could be divided into four types:①total occlusion;②partial occlusion;③sparse image and slow blood flow;④diffuse blood vessels tenuity and rigidity.Type ① and type ② were the commonest,account for 42.0% and 30.2% respectively.The size of the lesion was correlative to the degree of occlusion.MRA was done again in 18 cases after therapy for 21￣28 days.In 9 cases of type ①,5 of massive cerebral infarction with total occlusion revealed recirculation and bleeding lesions.The other 4 cases did not show any changes in vessel figures but had lateral circulation and the lesions become smaller.Application of vasodilators may promote the establishment of lateral circulation for non massive cerebral infarction and then be helpful to improve the blood supply of the lesion.