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陕西省不同肝炎患者及献血者中SENV-H DNA的检测 被引量：1

Detection of SEN Virus H Subtype Infection in Different Hepatitis and Blood donors in Shan'xi
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摘要 目的探讨SEN病毒H亚型在陕西省不同肝炎患者和献血者中的感染情况。方法采用巢式聚合酶链反应方法对收集的健康献血者和各型肝炎患者的血样(包括甲肝、乙肝、丙肝和非甲-非戊型肝炎患者)共计754份,进行SENV-H亚型DNA检测。结果SENV-H感染率在无偿献血者中为24.4%,在急性甲肝、慢性乙肝、慢性丙肝和非甲-非戊型肝炎患者中分别为32.7%、45.2%、65.0%和43.9%。结论SENV与HCV等经血传播病毒有相似的传播途径。 Objective To explore the prevalence of SENV-H in different patients with hepatitis and blood donors. Method The SENV-H subtype DNA was detected with method of nested PCR in 754 blood samples from different patients with hepatitis and healthy blood donors in Shan＇xi province. Results The SENV-H positive rate was 24. 4% in healthy donors, 32.7 % in acute hepatitis A patients, 45.2 % in chronic hepatitis B patients,65.0 % in hepatitis C patients, 43.9 % in hepatitis non A-E patients. Conclusion SENV has similar path with HCV and other viruses spreading by transfusion.
作者 陈蕤 穆士杰 李丁 张献清
机构地区 第四军医大学西京医院输血科 第四军医大学基因诊断技术研究所
出处 《临床输血与检验》 CAS 2006年第4期280-282,共3页 Journal of Clinical Transfusion and Laboratory Medicine
关键词 SENV-H亚型 流行病学 巢式聚合酶链反应 SENV-H subtype ,Epidemiology ,Nested PCR
分类号 R512.6 [医药卫生—内科学]
  • 相关文献

参考文献11

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二级参考文献5

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共引文献7

同被引文献8

  • 1TANAKA Y, PRIMI D, WANG RY, et al. Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family[J]. J Infect Dis, 2001, 183(3): 359-367,
  • 2SCHROTER M, .LAUFS R, ZOLLNER B, et al, Prevalence of SENV-H viraemia among healthy subjects and individuals at risk for parenterally transmitted diseases in Germany[J]. J Viral Hepat, 2002, 9(6): 455--459.
  • 3BOWDEN S. New hepatitis viruses: contenders and pretenders[J]. J Gastroenterol Hepatol, 2001, 16(2): 124-131
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  • 5UMEMURA T, TANAKA E, OSTAPOWICZ G, et al. Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis [J]. J Infect Dis, 2003, 188 (10): 1545-1552.
  • 6KOJIMA H, KAITA KD, ZHANG M, et al. Genomic analysis of a recently identified virus (SEN virus) and genotypes D and H by polymerase chain reaction [J]. Antiviral Res, 2003, 60 (1): 27-33.
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  • 8SCHROTER M, LAUFS R, ZOLLNER B, et al. A novel DNA virus (SEN) among patients on maintenance hemodialysis: prevalence and clinical importance [J]. J Clin Virol, 2003, 27 (1): 69-73.

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临床输血与检验
2006年 第4期

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