创伤性脑损伤认知障碍烟碱型胆碱受体的研究进展

Advancement of the Study of Nicotinic Acetylcholine Receptors in Cognitive Deficits Induced by Traumatic Brain Injury

创伤性脑损伤是创伤医学、急救医学的重要研究课题,其发生率高、后遗症多,其中学习记忆(认知)能力的损害是最持久和最严重的症状之一,严重影响患者的正常生活和工作,然而认知障碍与烟碱型胆碱能受体间的关系越来越受到关注,现就烟碱型胆碱能受体的研究进展及与脑创伤和学习记忆间的关系予以综述.

Traumatic brain injury （TBI） has become an important study in traumatic medicine and emergency medicine according to high incidence and sequela. Especially, the impairment of learn and memory （cognition） is one of the most persistent and serious symptom, which affects severely the suffers＇ normal life and work. However, nowadays, researchers pay more and more attention to the relationship between cognitive deficits and nicotinic acetylcholine receptors. This review is about to the advancement of the study of nicotinic acetylcholine receptors and the relationship between nicotinic acetylcholine receptors and learning and memory induced by TBI.