表皮生长因子受体在鼻咽癌及癌前病变组织中的表达

Expression of EGFR in nasopharyngeal carcinoma and precancerous lesson

运用免疫组织化学标记链霉菌素─生物素技术（ＬＳＡＢ），检测表皮生长因子受体（ＥＧＦＲ）在正常鼻咽粘膜、鼻咽粘膜异型增生和鼻咽癌中的表达，发现鼻咽正常粘膜全部为阴性，异型增生阳性表达率较低，而一旦鼻咽粘膜癌变后，表达率明显升高。ＥＧＦＲ的表达与鼻咽癌的低分化性相关；ＥＧＦＲ表达的肿瘤易发生淋巴结转移，５年生存率较低。提示ＥＧＦＲ的表达与鼻咽癌的发生有一定关系，并可作为判断鼻咽癌生物行为和预后的一个有用指标。

The expression of epidermal growth factor recepter (EGFR) in normal nasopharyn geal mucosa, nasopharyngeal mucosal dysplasia and nasopharyngeal carcinoma(NPC) was studied with immunohistochemical LSAB (lablled streptavidin biotin) method. Normal nasopharyngeal mu cosa was dvoid of while the staining was found in dysplasia. When NPC occurred,the positive rate increased. The expression of EGFR was related to the poor differentiation of NPC. The carcinoma with the expression was easy to metastasize to lymph nodes,and the 5 year survival rate of patients was lower.It is suggested that EGFR might play some role in the process of cercinogenesis of na sopharyngeal mucosa,and be used as a useful marker for the assessment of the biological behavior and prognosis of NPC.