诱导化疗对鼻咽癌病人白细胞介素2活性及其受体反应性的影响

A primary study on the effect of induction chemotherapy on activity of interleukin-2 and its receptors in patients with NPC

７６例局部中、晚期初治鼻咽癌患者，放疗前被随机分成动脉灌注化疗（ＩＡＣＴ）和全身化疗（ＳＣＴ）两组，接受相同的联合方案（顺氯氨铂、５－氟脲嘧啶、平阳霉素和烟酰胺）治疗，观察两组的白细胞介素２活性（ＩＬ－２）和白细胞介素２受体（ＩＬ－２Ｒ）反应性的变化。结果表明；两组化疗前后各自的ＩＬ－２活性并无下降（Ｐ＞０．０５），而ＩＬ－２Ｒ反应性均有提高（Ｐ＜０．０５），两组相比，ＩＡＣＴ组的ＩＬ－２Ｒ改善又较ＳＣＴ组明显（Ｐ＜０．０５）。认为诱导化疗通过改善ＩＬ－２诱导的细胞免疫功能，可能是远期生存率得以提高的原因之一，并就诱导化疗方案的设计进行讨论。

The chemotherapy was given to 76 patients diangnosed as locally advanced nasopha ryngeal cercinoma(NPC) before radiation. Two different methods of chemotherapy were used:in traarterial(IACT) and systemic(SCT),but the regimen used was the same combination of DDP,5 Fu,BLM and nicotinamide. The effect of both methods on activity of interleukin-2(IL-2)and its re ceptors (IL-2R) in these patients was compared. The results showed that IL-2 activity significantly improved(P<0.05) after chemotherapy in both methods,and the improved of IL-2R activity was significant better in IACT than SCT( P<0.05). It is suggested that the improvement of cellular immunity mediated by IL-might be of benefit to long-term survival with induction chemotherapy before radiation. And the method and regimen used in induction chemotherapy was discussed.