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GSTT1、GSTM1基因多态性与重度慢性牙周炎易感性关系的研究 被引量：1

Study on Relationship between Polymorphisms of GSTT1 and GSTM1 genes and susceptibility to severe chronic periodontitis
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摘要 目的:研究GSTT1+/0和GSTM1+/0基因型及其联合基因型与重度慢性牙周炎(chronic periodontitis,CP)易感性的关系。方法:用聚合酶链反应检测50例重度慢性牙周炎患者和51例正常对照者的GSTT1+/0、GSTM1+/0的基因型。结果:GSTM1(0/0)和GSTT1(0/0)基因型及GSTM1(0/0)与GSTT1(0/0)联合基因型对重度慢性牙周炎相对危险度(OR)分别为9.56(95%CI,3.88-23.59),8.68(95%CI,3.50-21.51),36.83(95%CI,10.42-130.13)。结论:在内蒙古汉族人群中,基因型GSTT1(0/0)和GSTM1(0/0)增加了个体对重度慢性牙周炎易感性,且上述两种基因型间存在协同作用。 Objective： To investigate the polymorphisms of GSTT1 and GSTM1 genes as well as their separate and combined effects on susceptibility to severe chronic periodontitis. Methods： In the 50 patients with chronic severe periedontitis and 51 healthy controls, the genotypes of GSTrl ＋/0 and GSTM1 ＋/0 polymorphisms were detected by PCR. Results： Individuals with genotype（0/0）of GSTM1, genotype（0/0） of GSTT1, combined genotypes GSTMI（0/0） and GSTT1（0/0）had more relative risks than those with the corresponding common genotypes, whose ratios were 9.56（95%CI 3.88-23.59）, 8.68（95%CI 3.50-21.51）, 36.83（95%CI 10.42- 130.13）. Conclusion： There is a synergy of susceptible genotypes GSTM1 （0/0） and GSTT1（0/0） to enhance the individual susceptibility to chronic severe periedontitis.
作者 张巨峰 周立社 彭志平 秦文斌 雎天林
机构地区 上海交通大学附属第一人民医院中心实验室 包头医学院生物化学教研室 包头市中心医院检验科
出处 《现代生物医学进展》 CAS 2006年第8期28-30,共3页 Progress in Modern Biomedicine
关键词 慢性牙周炎 基因多态性 GSTT1基因 GSTM1基因 易感性 Gene polymorphisms GSIT1 gene GSTM1 gene Susceptibility Chronic periedontitis
分类号 Q346.5 [生物学—遗传学]
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参考文献19

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共引文献10

同被引文献8

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现代生物医学进展
2006年 第8期

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