胃腺癌神经浸润的临床病理学意义

Clinical and pathological significance of neural invasion of gastric adenocarcinoma.

目的研究胃腺癌(Gastricadenocarcinoma,GAC)神经组织浸润与临床病理学指标的关系。方法复习95例GAC组织常规切片,分析GAC的神经组织浸润与性别、年龄、组织学分化程度、肿瘤浸润深度、淋巴结转移、临床分期和肝、肺、卵巢转移等生物学行为的关系。结果95例GAC神经组织浸润的发生率为56%,神经组织浸润与肿瘤浸润深度、淋巴结转移和临床分期均呈正相关(P分别为0.000、0.010和0.004,r分别为0.492、0.265和0.293),与性别、年龄、组织学分化程度和肝、肺、卵巢转移均无关(P>0.05)。结论GAC的神经组织浸润与肿瘤的浸润深度、淋巴结转移和临床分期等生物学行为有密切关系,提示发生神经组织浸润的GAC具有较强的浸润和转移能力。

Objective To investigate the relationship between neural invasion and clinical pathological indexes in gastric adenocarcinoma（GAC） patients. Methods 95 GAC cases were reviewed. The relationship between neural invasion and clinical pathological indexes of GAC was analyzed. Results The neural invasion rate was 56% （53/95） in GAC patients. The neural invasion rate was positively correlated with invasive depth, lymphoid metastasis, and clinical stage （ P = 0.000, 0.010 and 0.004）. No relationship was found between the neural invasion and age, sex, differentiation, and distal metastasis （ P 〉 0.05）. Conclusion The neural invasion of GAC tissues was closely related with the invasive depth, lymphoid metastasis and clinical stage. It suggests that the GAC with neural invasion might be potential in invasion and metastasis.