国产鼻喷鲑鱼降钙素治疗骨质疏松性疼痛的疗效观察

Curative Effect Observation on Nasal Spray of Salmon Calcitonin in Treating Osteoporosis Pain

目的观察国产鼻喷鲑鱼降钙素治疗骨质疏松性疼痛的疗效。方法采用随机分组对照设计。选择骨质疏松患者53例,随机分为两组,治疗组(30例)给予鼻喷鲑鱼降钙素,20u/次,1次/天,8周为1个疗程,停药后继续观察3周。对照组(23例)口服钙尔奇D片,1片/次,1次/天,共8周;采用国际惯用分级标准对疼痛予以评估。结果治疗组患者的疼痛明显改善,其总有效率为95%;在停药后缓解疼痛的作用仍可维持4周以上,Ⅲ度骨质疏松患者的治疗效果较Ⅰ度和Ⅱ度患者的效果差;对照组症状未见明显改善。结论用国产鼻喷鲑鱼降钙素治疗骨质疏松性骨痛,可明显缓解患者的疼痛症状。

Objective To observe the curative effect of nasal spray of salmon calcitonin in treating ostcoporosis pain. Methods 53 eases with osteoporosis were randomly divided into 2 groups：treatment group （30 cases） and control group （23 cases） ;The treatment group was given nasa] spray of salmon calcitonin, 20U/once, once/day, 8 weeks/course, the observation kept on for 3 weeks after drug withdrawal;the control group was given Compound Calcium Carbonate, 1 pill/once, once/day, 8 weeks/course. Results The symptoms in treatment group improved significantly,the total effective rate was 95% ,and pain-relief kept on for 4 weeks after drug withdrawal, the curative effect in patients with osteoporosis Grade Ⅰ and Grade Ⅱ was better than that in patients with osteoporosis Grad Ⅲ .The patients in control group showed no significant improvement. Conclusions Nasal spray of salmon calcitonin is effective in treating osteoporosis and can significantly relieve the pain.