术前提高血钙浓度对剖宫产产后出血的影响

Clinical Trial in the Efficacy and Safety of Calcium Gluconate to Prevent Flooding Among Cesarean Case

目的:探讨术前应用葡萄糖酸钙对剖宫产产后出血的有效性及安全性。方法:对709例患者采用随机对照的方法进行研究。研究组术前30 min静脉滴注10%葡萄糖酸钙10 mL,对照组静脉滴注生理盐水100 mL,分别于术中胎儿娩出时、术后2 h测定血清钙离子的浓度,并用容积法和称重法对两组出血量进行对比观察。结果:胎儿娩出时和术后2 h研究组血清钙高于对照组(P<0.01);研究组平均出血量和产后出血的发生率低于对照组(P<0.01);术前血钙浓度高的产后出血量少(P<0.01);不同剖宫产指征的出血量比较研究组低于对照组(P<0.01);各项指标均具统计学意义。结论:术前提高血钙浓度可减少剖宫产产后出血量,并未见副作用。

Objective：To evaluate the clinical efficacy and safety of calcium gluconate to prevent flooding among serum calcium deepness up to snuff cesarean cases. Methods： Controlled randomized study was made in serum calcium deepness up to snuff cesarean in 709 cases. Treatment cesarean case with 10% calcium gluconate 10 mL drop at 30 min to cesarean in the study group and with physiological saline solution 100 mL in the control group. Mensurated serum calcium deepness at fetus childbirth and 2 hour past cesarean and observed（cubage and weigh）quantity of the flooding in each group. Results： The datum of serum calcium deepness at fetus childbirth and 2 hour past cesarean was higher in the study group than that in control group;the rate and quantity of the flooding was lower in study group than that in control group;the quantity of the flooding was little in the group with a higher serum level of calcium before operation than that in the group with lower level;the quantity of the flooding was little in the study group of each operation cause than control group. There was significantly statistics in each index. Conclusion： Data from the study showed that treatment with calcium gluconate to prevent flooding is effective and safe among serum calcium deepness up to snuff cesarean cases, and there were not side effect.