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Na-K-2Cl共同转运蛋白(NKCC2)基因研究进展 被引量:4

Advance in the Research of Na-K-2CI Cotransporter(NKCC2)Gene
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摘要 Na-K-2Cl共同转运体在维持肾小管髓袢升支粗段对NaCl的重吸收、机体容量控制方面起重要作用,NKCC2基因突变可使其编码的蛋白质结构、功能改变,使体内血压调节的稳态发生变化。 Na-K-2Cl-cotransporter (NKCC2) plays important roles in reabs-orption of NaC1 from the fluid in the thick ascending limb of Henle' s loop (TAL) and volume control. The mutation of NKCC2 gene can alter the structure and functions of Na-K-2C1 cotransporter, which leads to changes in blood pressure regulation homeostasis.
出处 《国际遗传学杂志》 CAS 2006年第4期260-263,共4页 International Journal of Genetics
基金 国家自然科学基金(No.C03030201) 国家863预研项目(No.国科生字[2000]112号)
关键词 Na-K-2C1共转运体 NKCC2基因 突变 血压 Na-K-2Cl-cotransporter(NKCC2) NKCC2 gene Mutation Blood pressure
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