摘要
FcγR家族属于免疫球蛋白超家族,分三群,其中FcγRⅡa、Ⅱb、Ⅲa和Ⅲb存在基因多态性,并因此影响FcγR和IgG各亚型的亲和力,被认为与SLE发病过程中免疫复合物清除有关,导致SLE和狼疮肾炎的发生。FcγR基因多态性与SLE发病关系在不同种族人群中的研究结果不一致,但仍可认为FcγR基因是某些种群SLE发病的易感基因。
Receptors for the Fc domain of IgG（FcγR） are mainly expressed as hematopoetic cell surface molecules and constitute a crucial link between humoral and cellular immunities. There are three distinct classes of FcγR molecules （ FcγR I , FcγR Ⅱ and FcγR Ⅲ ）. Recent evidence suggests that certain FcγR alleles （ FcγR Ⅱ a,Ⅱb ,Ⅲ a and Ⅲ b） are genetic risk factors for systemic lupus erythematosus and lupus nephritis, because the polymorphisms are involving in immune complex clearance in susceptibility of lupus. Correlation of the FcγR polymorphisms with susceptibility of SLE has been reported in various populations, but the results were inconsistent.
出处
《国际遗传学杂志》
CAS
2006年第4期303-306,共4页
International Journal of Genetics
基金
国家自然科学基金项目(No.3037124730571608)
