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BCR/ABL融合基因与慢性粒细胞白血病的发生 被引量：3

The BCR/ABL Fusion Gene and the Nosogenesis of Chronic Myelocytic Leukemia
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摘要 BCR/ABL融合基因是一个重要的凋亡抑制基因,具有较强的PTK活性。src激酶、蛋白激酶家族C、信号转导和转录激活因子(STAT)等在BCR/ABL融合基因介导的肿瘤恶性转化中起着重要的作用。 The BCR/ABL fusion gene is an important inhibiting gene of apoptosis and displays higher protein tyrosine kinases activity. The fusion gene activates a number of signaling molecules including SRC kinases, PKC,STAT, which may play an important role in tumor malignant transformation.
作者 陈晓玲 魏莎莉
机构地区 重庆医科大学公共卫生学院生殖生理教研室
出处 《国际遗传学杂志》 CAS 2006年第4期307-310,共4页 International Journal of Genetics
关键词 BCR/ABL融合基因 蛋白酪氨酸激酶 信号转导 The BCR/ABL fusion gene Protein tyrosine kinase Signal transduction
分类号 R733.72 [医药卫生—肿瘤]
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参考文献20

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二级参考文献8

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  • 6徐冬,宋俊敏,呼莹,郭虹,曹德骏,汪萍,刘辉,赵春华.抗ABL酪氨酸激酶区胞内抗体对K562细胞在裸鼠体内生长的影响[J].中国医学科学院学报,2002,24(1):11-14. 被引量：4
  • 7刘艳荣,于弘,常艳,陈珊珊.四色荧光标记抗体在白血病免疫分型中的应用及意义[J].中国实验血液学杂志,2002,10(5):423-427. 被引量：43
  • 8秦亚溱,刘艳荣,李金兰,王卉,常艳,付家瑜,阮国瑞,丘镜滢,陆道培,陈珊珊.慢性髓系白血病不同bcrabl融合基因转录子与临床关系的研究[J].中华血液学杂志,2003,24(7):347-350. 被引量：20

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国际遗传学杂志
2006年 第4期

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