脂肪肝与肥胖、血脂异常、糖尿病的相关性探讨

The Exploration of Correlation Between Fatty Liver and Obesity,Dyslipidemia,Diabetes Mellitus

目的探讨脂肪肝与肥胖、血脂异常、糖尿病的相关性。方法对参加健康体检的534名机关干部,测量身高、体重,行血脂、血糖、肝肾功能等生化检查,同时行腹部B超、心电图、胸片等检查,并将检查资料录入微机,进行脂肪肝组和非脂肪肝组的对比分析。结果(1)体质指数(BMI)≥28者脂肪肝检出率为65.38%,BMI<28者脂肪肝检出率为16.45%,肥胖患者脂肪肝检出率明显高于非肥胖者(P<0.01);(2)脂肪肝组的BMI、血甘油三酯(TG)、血高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、餐后2 h血糖(PBG 2 h)水平与非脂肪肝组比较,差异有统计学意义(P<0.01);(3)脂肪肝组中并存肥胖症、高TG血症、低HDL-C血症、糖尿病的发生率显著高于非脂肪肝组(P<0.01)。结论肥胖、高TG血症、低HDL-C血症、糖尿病与脂肪肝的发病密切相关;减轻体重、纠正血脂异常、降低糖尿病患者的血糖对防治脂肪肝具有重要的临床意义。

Objective To explore the correlation between fatty liver and obesity, dyslipidemia, diabetes mellitus. Methods 534 cases of officials who came to take part in the healthy examination had received measurements of their level lipids, blood glucose, liver, renal function of their bloods and their heights and weights; inspection of liver and kidney by B ultrasonic; electrocardiogram（ECG）,chest- X- ray. The data were recorded by computer. The populations suffered by fatty were compared with those without. Results （1） Among cases of the body mass index （BMI）≥ 28, the rates of which suffered by fatty liver were 65.38%, and among thoss of BMI 〈 28, the rates were 16.45 %. The rates of fatty liver companied by obesity Were higher than those of non - obesity（ P 〈 0.01 ）. （ 2 ） There were positive differences of their BMI, blood triglyceride （TG）, high density lipoprotein- cholesterol （HDL- C）, fasting blood glucose（ FBG）, 2- hour postprandial blood glucose（PBG2h） between the fatty liver and the non- fatty liver cases（ P 〈 0.01 ）. （3）The incidences of obesity, hypertriglyceridemia , low HDL - C, diabetes mellitus （ DM ） in fatty liver group were significantly higher than that of non - fatty liver group（ P 〈 0.01 ）. Conclusion Obesity, hypertriglyceridemia, low HDL- C and DM were closely related with fatty liver; Losing body weight, redressing the abnormality of blood lipid and decreasing the serum glucose of the DM are the most important ways to prevent the fatty liver.