正交设计优选板蓝根蒲公英颗粒制备工艺

Orthogonal Experiments to Select Spray-Drier Technological Preparation for Banlangenpugongying Granules

目的 为提高板蓝根蒲公英颗粒的成品率及提高工作效率，需要筛选制备工艺。方法 采用新型喷雾干燥制粒机制粒，以浸膏的提取工艺、进液速度、进出口的风温及辅料的配比为考察因素，每个因素2个水平，以颗粒的成品率为考察指标，采用正交设计法优选出最佳喷雾干燥制备工艺。结果 四因素中以辅料的配比及进出口风的温度影响最为明显，其次为进液速度，浸膏的提取工艺影响不大。结论 板蓝根蒲公英颗粒最佳的喷雾干燥工艺条件为蔗糖与糊精的配比为4：1；进风口的温度为80-90℃；出风口的温度为40-50℃；进液速度为4；提取液以经过醇沉为佳。

Objective To raise the end -product and efficiency of Banlangenpugongying Granules, preparation technologies should be screened, Methods Adopting newly spraying -drier- granulation technology, taking extracting technology, fluid entering speed, temperature of exit and entry, and the matching of accessories as inspecting factors, two levels of each factors, end - product as inspecting marker, we selected the best Banlangenpugongying Granules preparation technology by orthogonal design. Results Among the 4 factors, the matching of accessories and the temperature of exit and entry are the most notable, next is the fluid entering speed, extracting technology is of little importance. Conclusion The optimum spraying - drier - granulation tech- nology of Banlangenpugongying Granules is A1 B1 C2D1.