中老年糖尿病肾病骨矿含量变化及其意义探讨

HE CHANG OF BMD IN OLD AND MIDDLE AGE PATIENTS WITH DIABETIC NEPHROPATHY AND ITS SIDNIFICANCE PROBING

为了探讨中老年糖尿病肾病和非肾病患者的骨密度的关系，对１７８例４０岁以上的糖尿病患者用单光子骨矿含量测定仪检测了挠骨骨密度（ＢＭＤ）．并根据２４小时尿蛋白定量分成Ａ、Ｂ、Ｃ三组。结果表明，ＢＭＤ测定值，Ａ组７２例中９例降低，Ｂ组８７例中有３８例降低，Ｃ组１９例有１５例降低。ＢＭＤ降低率分别为１２．５％、４３．２％及７８．９％。Ａ、Ｃ组间ＢＭＤ值差异非常显著（Ｐ＜０．０１），说明ＢＭＤ降低与尿蛋白排泄量有关，因此，可将ＢＭＤ测定作为临床监测糖尿病肾病患者骨代谢紊乱的指标之一。

n order to find out the relationship of BMD between middle or old aged diabetics whocomplicated with and not with nephropathy,the BMD of radiums had been measured with single-photo bene nnneral analyzer on 178 diabetics above a ge of 40 yrs。The patients were divided intogroup A,B,C,according to the amounts of protein in 24 hrs urine。The measureing and studyingresults showed that there were 9 cases decreasing in BMD among 72 cases in group A,38 casesdecreaaing among 87 cases in group B,and 15 cases decreasing among 19 cases in group C. Thereduction rate of BMD were 12.5%,43,2%and 78. 9% repectivey.The difference in value of BMDbetween group A and group C was significiant (P<0.01).It also showed that the reduction of BMDhas something to do with the excretive amounts of urine protein。So the value of BMD can beregarded as one of the indexs for monitoring of bone metabolism disturbance in diabeticnephropathy.