摘要
观察茶多酚对异丙肾上腺素（Ｌｓｏ）诱致心肌损伤的保护作用实验时，意外发现混旋普萘洛尔（Ｌ，Ｄ－ｐｒｏ）和右旋普萘洛尔（Ｄ－ｐｒｏ）与茶多酚一样，均使大鼠血清ＭＤＡ降低，抑制Ｉｓｏ诱致心肌损伤时ＣＰＫ、ＬＤＨ和ＬＤＨ１的升高，提高ＬＤＨ２／ＬＤＨ１比值，减轻异丙肾上腺素诱致心肌损伤的程度。提示阻滞心脏β受体，并非为Ｌ，Ｄ－ｐｒｏ保护Ｉ５０诱致心肌损伤的唯一机理，其强有力的直接清除氧自由基作用，可能是另一机理。
When we observed protective effect of Tea polyphenol on isoprenaline-induced myocardial injury in rats,we found by chance D-pro and L,D-pro,like Tea polyphenol,could decrease serum maionydialdehyde concentration,creatine phosphokinase activity,lactic dehydrogenase(LDH)activity and LDH1 activity,increase LDH2/LDH1 ratio,and inhibit the extent of myocardial injury.The results suggest that β-adrenoceptor blockade of L,D-pro is not the only mechanism of protective effect on isoprenaline-induced myocardiai injury and the role of its anti-oxygen free radical may be another mechanism.
出处
《皖南医学院学报》
CAS
1996年第4期313-315,共3页
Journal of Wannan Medical College
