大肠癌伴血吸虫病的病理与粘液组织化学研究

THE PATHOLOGICAL AND HISTOCHEMICAL STUDIES OF THE LARGE BOWEL ADENOCACINOMA ASSOCIATED WITH SCHISTOSOMIASIS

对８６例经手术切除的大肠癌标本（伴血吸虫病４０例，不伴血吸虫病４８例）进行了系统观察与对比。除常规病理检查外，对其中４０例（伴与不伴血吸虫病各２０例）做粘液组织化学检查。结果表明，伴血吸虫病组的大肠癌在发病年龄上有提前趋势，发病部位以乙状结肠相对多见，患者的性别、肿瘤的大小以及肉眼类型上并无明显差异，肿瘤的大小以及肉眼类型上并无明显差别。两组癌旁粘膜均表现出移行粘膜的粘液组织化学改变，但其中以伴血吸虫病组大肠癌的改变尤为明显，作者认为。

Resected large bowel adenocarcinoma specimens were studied in 86 cases. Among them 40 cases were schistosomiasis associated(SA) and 46 cases were non-schistosomiasis associated(SN).Both groups were comparatively observed by routine pathological technique,and 40 cases(20 cases in both SA and SN groups) were examined by mucin histochemical method.the conclusion showed that,there were some differences between the SA and SN group in the age,tumor site,Duke's stage and histological type,but no significant difference in sex,tumor size,and gross appearence.The paracancerous mucosa in both gruops showed the same characteristics of mucin histochemical changes of the' transitional mucosa'i.e.sulpho-mucin decreased and saliomucin increased markly,espicialy in SA group.the authour suggest that the histochemical changes of mucins in the paracancerous mucosa of the SA group may be of the dual effects by both carcinogens and schistosomiasis.