抗内皮细胞抗体与系统性红斑狼疮发病关系的探讨

CLINCAL SIGNIFICANCE OF ANTI-ENDOTHELIAL CELL ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

为研究抗内皮细胞抗体（ＡＥＣＡ）与系统性红斑狼疮（ＳＬＥ）发病之间的关系，我们检测了４０例ＳＬＥ病人血中ＡＥＣＡ，并同步检测血浆中内皮素（ＥＴ）水平。结果显示ＳＬＥ病人ＡＥＣＡ阳性率明显较对照组为高，ＡＥＣＡ阳性的ＳＬＥ病人浆膜炎、肾损害发生率较ＡＥＣＡ阴性病人明显增高，ＡＥＣＡ阳性组ＥＴ浓度也明显增高。揭示ＡＥＣＡ不仅直接参与ＳＬＥ发病，还可通过刺激内皮细胞释放ＥＴ，从而加重ＳＬＥ，尤其狼疮肾炎的症状。

Plasma anti-endothelial cell antibodies(AECA) & and endothelin(ET) leves were studied in forty patients with systemic lupus erythematosus(SLE) to reveal the relationship between AECA and the etiology of SLE.The result showed taht the positive rate of AECA in the SLE patients was much higher than that in normal controls.A significant correlation was found between the presence of AECA and kidney injury,serositis.The patients with positive AECA had a higher plasma ET levels than those without AECA.These data suggest that A ECA plays an important role in the etiology of SLE.