人体囊虫病特异性抗体IgG、IgM和IgA测定临床意义的探讨

CLINICAL SIGNIFICANCE IN THE DETERMINATION OF SPECIFIC IgG、IgM AND IgA IN PATIENTS WITH CYSTICERCOSIS

应用ＥＬＩＳＡ法测定４２例囊虫病人用吡喹酮治疗前血清、脑脊液和治疗后２个月血清ＩｇＧ、ＩｇＭ和ＩｇＡ。结果显示：治疗前血清特异性抗体阳性率分别为ＩｇＧ９５．２３％，ＩｇＭ９２．８５％和ＩｇＡ９０．４７％；治疗后２个月分别为ＩｇＧ９５．２３％，ＩｇＭ９２．８５％，ＩｇＡ８８．０９％。治疗前后三种血清抗体比较无显著性差异（Ｐ＞０．０５）。治疗前脑脊液抗体分别为ＩｇＧ８５．７１％，ＩｇＭ９５．２３％和ＩｇＡ９２．８５％。提示：囊虫可溶性抗原可刺激Ｂ淋巴细胞产生ＩｇＧ、ＩｇＭ和ＩｇＡ特异性抗体，诱发抗体介导的免疫反应。

Serum and cerebrospinal fluid (CSF) IgG、IgM and IgA were detected by ELISA in 42 patients with cysticercosis before and after praziquantel treatment The results showed that the positive rates of IgG、IgM and IgA in the serum were 95 23%,92 85% and 90 47%,respectively befor treatment;After treatment the positive rates of IgG、IgM and IgA in the serum were 95 23%,92 85 and 88 09% respectively There were not much differences in these three serum antibodies before and after treatment ( P >0 05) The positive rates of IgG、IgM and IgA in CSF were 85 71%,95 23% and 92 85%,respectively The results suggested that the cysticercus soluble antigen might stimulate the B lymphocytes to produce specific IgG、IgM and IgA,and induce humoral mediated immunity