子痫前期患者胎盘组织TGF-β_1、TGFβRⅠ和TGFβRⅡ的表达及其意义

The expression of TGF-β_1 ,TGFβR Ⅰ and TGFβR Ⅱ and their significance in placenta of pregnant women with preeclampsia

目的检测胎盘组织中TGF-β1(transforming growth factor-beta1,TGF-β1)及其受体(TGF-beta receptor,typeⅠandtypeⅡ,TGFβRⅠ,TGFβRⅡ)的表达,评估TGF-β1及其受体在子痫前期发病中的作用。方法采用SP免疫组化法检测正常妊娠组和轻、重度子痫前期组胎盘组织中TGF-β1、TGFβRⅠ和TGFβRⅡ的分布与定位,并通过高清晰度彩色病理图像分析系统对其进行定量分析。结果重度子痫前期组TGF-β1和TGFβRII的平均光密度较正常妊娠组显著增加(P<0·01),TGFβRI的平均光密度也较正常妊娠组增加(P<0·05)。结论TGF-β1、TGFβRI和TGFβRII在滋养细胞的浸润过程中发挥重要作用,它们可能与子痫前期的发病有着重大的关系。

Objective ： To detect the expression of transforming growth factorbeta1 （TGF-β1 ） and its receptors （TGFβR Ⅰ and TGFβR Ⅱ ） in placentas, and to evaluate the roles of TGF-β1 and its receptors in preeclampsia, methods ： Immunohistochemistry （SP） was used to investigate the distribution and location of TGF-β1, TGFβR Ⅰ and TGFβR Ⅱ in placenta tissues of normal pregnant women and women with preeclampsia, Highly precise color - image measure system was taken advantage for quantitative analysis. Results ： The mean density of TGF-β1 and TGFβR Ⅱ in serious group of preeclampsia was significantly higher than that in normal group （ P 〈0.01）, the mean density of TGFβR Ⅰ was also increased （ P 〈0.05）. Conclusion： TGF-β1 and its receptors play an important role in the shallow invasion of trophoblast, they may be associated with the pathogenic causes of preeclampsia.