妊娠高血压疾病与偶联因子、前列环素的相关性研究

Study on association of coupling factors and prostacyclin in hypertensive disorder complicating pregnancy

目的通过对不同程度、不同孕周妊娠高血压疾病患者、正常孕妇血管内皮细胞活性物质—偶联因子6(CF6)、前列环素I2(PGI2)的检测,探讨其与妊娠高血压疾病发病的相关性。方法选择妊娠高血压疾病患者36例作为研究组,再选同期与之孕周、年龄相匹配的正常孕妇33例作为对照组,采用放射免疫方法检测CF6、PGI2的血浆含量。结果研究组CF6水平明显高于对照组,分别为491.5±95.3(pg/ml);255.3±75.5(pg/ml),两组比较,P<0.01,有极显著性差异;研究组PGI2水平低于对照组,分别为133.5±76.7pg/ml;216.6±89.1(pg/ml),P<0.05,有显著性差异。研究组平均动脉压(MAP)、产时出血量多于对照组,而新生儿体重、Apgar评分均低于对照组,P<0.01,有显著性差异。结论CF6、PGI2两种血管活性物质的失调可能在妊娠高血压疾病的形成过程产生重要的作用。

Objective： To detected vascular endothelial cells avtivator （VECA） coupling factors 6 and prostacyclin 12 in different degree, different weeks of gestation hypertensive disorder complicating pregnancy and normalpregnant women, and to analyze the relationship between VECA and pathogenesis of hypertensive disorder complicating pregnancy and normalpregnant women, and to analyze the relationship between VECA and pathogenesis of hypertensive disorder complicating pregnancy and normalpregnant women, and to analyze the relationship between VECA and pathogenesis of hypertensive disorder complicating pregnancy. Methods： Thirty - six women with hypertensive disorder complicating pregnancy （ study group） and thirty - three normal pregnant women （ control group） were studied, the data of the weeks of gestation and age in two groups were comparable at enrolment. CF6 and PGI2 were evaluated by radio immunoassay. Results： The mean concentration of CF 491.5±95.3 （pg/ml） of the study group was significantly higher than that 255.3±75.5 （pg/ml） of the control group （ P 〈 0. 01 ）. The mean concentration of PGI2 133.5± 76.7 （pg/ml） of the study group was lower than that 216.6 ±89. 1 （pg/ml） of the control group （ P 〈 0. 05 ）. The mean amount of parturition bleeding and MAP of the study group higlier than that of the control group, newborn weight arid Apgar of the study group lower than that of the control group （ P 〈0. 01 ）. Conclusion ： Dysfunctional in two VECA of CF6 and PGI2 plays an important role in development of hypertensive disorder complicating pregnancy.