长效胰岛素类似物

Recent Development of Long-acting Insulin Analogs

综述几类能有效调控血糖的长效胰岛素类似物,如甘精胰岛素、脂肪酸酰化胰岛素、胰岛素前体类似物、PEG化胰岛素、胰岛素类似物聚合体等的性质、作用机制、免疫原性及组织选择性。新型长效胰岛素类似物的发现,克服了传统的长效胰岛素制剂存在的血药浓度峰谷明显、变异性高、夜间容易发生低血糖等缺点,为糖尿病的治疗开辟了新思路。

The previous long-acting insulin preparations show many disadvantages, such as blood concentration with obvious peak and valley value, high variance and causing frequent hypoglycemia during night. A series of novel long-acting insulin analogs regulating effectively blood glucose have been discovered.This provides a prosperous future for the therapy of diabetes. In this paper, some long-acting insulin analogs involving insulin glargine , fatty acid acylated insulin, proinsulin analogs, pegylated insulin and conglomeration of insulin analogs were reviewed in respect to their properties, mechanisms, immunogenicity and tissue selectivity.