急淋患者外周血淋巴细胞糖皮质激素高、低亲和力结合位点的研究

HAGSandLAGSinperipherallymphocytesofacutelymphotic1eukemia

研究了１０例正常人和２９例急淋患者外周血淋巴细胞糖皮质激素高、低亲和力结合位点（ＨＡＧＳ、ＬＡＧＳ），对部分患者的ＨＡＧＳ、ＬＡＧＳ激素联合化疗前后水平的变化进行了动态观察。结果表明，正常对照组ＨＡＧＳ、ＬＡＧＳ分别为４６０８±１８８９位点／细胞和１３５２３５±８８５０９位点／细胞，两者相关良好ｑ急淋患者ＨＡＧＳ、ＬＡＧＳ分别是６０５２±３８８８位点／细胞和１２６４０５±１０２１３３位点／细胞。经过糖皮质激素类药物联合化疗后，其水平分别为３６１５±１９６２位点／细胞和１４３５９７±１１２２８９位点／细胞，ＨＡＧＳ下降明显（Ｐ＜０．００１），下降率为４０．３％，而ＬＡＧＳ化疗前后差异不显著（Ｐ＞０．０５）。提示，ＬＡＧＳ在介导糖皮质激素联合化疗疗效中起重要作用。

healthypersonsand29patientsofacutelymphoblasticleukemia(ALL)werestudiedconcerningtheirhighaffinityandlowaffinityglucocorticoidbindingsite(HAGS,LAGS)inperipherallymphocytes.ThedynamicchangesofHAGSandLAGSlevelswereobservedinsomepatientsbeforeandduringtheglucocorticoidchemotherapy.HAGSandLAGSincontrolgroupwere4608±1889sites/celland135235±88507sites/cellrespectively,andtheyhadagoodcorrelation.ThelevelsofHAGSandLAGSinALLgroupwers6052±3888sites/celland126405±102133sites/cell.Afterglucocorticoidchemotherapy,theybecame3615±1962sits/celland143597±112289sites/cellrespectively.HAGSdecreaseddramatieally( P <0.001),andthedecreasingratewas40.3%wheraseLAGSremainedunchangedduringthechemotherapy.ThisstroglysuggestedthatLAGSplayedanimportantroleinthemediationofglucocorticoidtherapy.