癫痫发作对大鼠学习记忆及生长抑素含量的影响

Theeffectofepilepsyonlearningandmemoryandthesomatostatincontentsinrats

在遗传性听源性癫痫大鼠模型上，采用了行为和放射免疫分析相结合的方法，研究了大鼠癫痫发作对光辨别学习的影响及心脑组织中生长抑素含量的改变。实验结果表明：（１）癫痫发作后，大鼠光辨别学习能力明显减弱，表现为达到学会标准所需的时间明显延长（Ｐ＜０．０１）：（２）癫痫发作后，大鼠下丘脑、海马、颞叶皮层、心肌组织中生长抑素含量明显增高（Ｐ＜０．０５～０．０１）。结果提示，癫痫发作对大鼠光辨学习有明显的抑制作用，该作用可能与下丘脑、海马、颞叶皮后及心肌组织中生长抑素含量的改变有关。

Theeffectofepilepsyonlightdiscriminationlearningandsomatostatin(SS)contentswerestudiedbymeansofbehaviorandradioimmunoassayingeneticallyepilepsy-pronerats,withamodelofaudiogenicepilepsy.Theresultswereasfnllows:(1)Theabilityoflightdiscriminationlearningwassignificantlyweakenedafterepilepsyseizure.ltshowedthatthetimereachingthestandardwasmarkedlyprolonged(P<0.01)andtherateofreachinglearningstandardwasdecreased(P<0.01).(2)TheSScontentsinhypothalamus,hippocampus,cerebralcortexandmyocardiumweresignificantlyincreasedaftterepilepsyseizure(P<0.01).(3)Whiletheabilityoflearningofratswasweakenedfollowingepilepsyseizure,theSScontentsintheseregionsweresignificantlyincreased(P<0.01).Theseresultsindicatedthatepilepsyseizureweakenedthelearningabilityofrats.Theef-fectmayberelatedtoSSinhypothalamus,hippocampus,cerebralcortexandmyocardium