利用血管生成模型计算实体肿瘤内的血液动力学

Computation of Hemodynamics in Solid Tumor Based on Model of Angiogenesis

肿瘤血管生成(Tumor-induced Angiogenesis)是指在实体肿瘤细胞诱导下毛细血管的生长以及肿瘤中血液微循环的建立。肿瘤内血液、组织液等流体流动在肿瘤药物输运过程中扮演着重要作用,而这些流动受到肿瘤内微血管网络结构的直接影响。目前要获得精确的肿瘤内外的毛细血管拓扑结构存在一定困难,因此给肿瘤内的血液动力学研究带来困难。本文根据肿瘤内外的复杂生理特性,建立肿瘤内外血管生成的二维离散模型,在获得相对真实的毛细血管网络拓扑结构基础上对肿瘤内的血液动力学进行初步计算,数值计算的结果加深了对肿瘤的复杂生理特性的理解,同时也给肿瘤内的药物输运给予一定的提示。

Tumor induced angiogenesis is the formations of new capillary and the blood micro-circulation of tumor from existed vessels under the inducement of solid tumor cells. Tumor-induced angiogenesis plays a significant role in tumor＇s growth and metastasis, in which the endothelia-cell is the most active member engaging in various stages. Fluid flows such as blood flow, interstitial fluid flow, etc., which are directly affected by the abnormal structure of solid tumor, play important roles in drug delivery. A better understanding of complicated fluid flow in solid tumor is great significant. At present it is not easy to accurately investigate the micro-vessel network of tumor, which makes some hard in the study of hemodynamics in tumor. A two dimensional discrete model of tumor induced angiogenesis, was presented, which can obtain the structure of tumor vascular network. Based on the network, the hemodynamics in solid tumor were studied. The results can enhance our understanding of complexity of tumor, and provide some suggestions for drug delivery in the treatment of tumor.