成人真菌性肠炎的临床特点及疗效分析

The clinical characters and treatment of adult mycosis intestinalis

目的分析真菌性肠炎的临床特点、治疗及疗效。方法对78例成人真菌性肠炎病例资料进行回顾性分析。治疗方案:单纯真菌性肠炎,症状轻者口服大蒜素胶囊180 mg^240 mg/d,症状较重加用达克宁栓200 mg纳肛1次/晚。合并其他部位脏器真菌感染者,静脉用氟康唑200 mg^400 mg/d或大蒜素注射液60~90 mg/d。部分患者加用大蒜素胶囊。结果显效76.4%,有效21%。结论真菌性肠炎好发危险因素主要有机体免疫力下降以及长期广谱抗菌素的应用。单纯真菌性肠炎,口服抗真菌药物,合并其他部位真菌感染者,多途径及联合应用药疗效可靠。确诊真菌感染不完全是停用抗生素的指征。

Objective To analyze the clinical characters and treatment of adult mycosis intestinalis. Methods and Results 78 cases of adult mycosis intestinalis were studied retrospectively. Allitid capsule 180 - 240 mg qd p. o was used to treat simple adult mycosis intesfinalis; miconazole nitrate suppository 200 mg qn p. recta was added in serious cases; fluconazole injection 200 - 400 mg qd or allitrid injection 60 - 90 mg qd in addition to allitrid capsule was administered in the cases of complex fungal infections. The rate of complete response was 78% and that of partial response was 21%. It was found that mycosis intestinalis was related to lowered immunity conditions of the body and long abuse of antibiotics, having no relationship to seasons. Conclusion Oral antifimgal drug is effective for simple adult mycosis intestinalis. Combination of antifungal drugs has credible efficacy in treating multi - organal mycosis, while antibiotics are only required in certain cases of mycosis.