5－氟尿嘧啶不同用药方式辅助青光眼滤过手术的实验研究

Effect of Different Methods for Application of Fluorouracil for Glaucoma Filtration Surgery in the Rabbit

术后结膜下注射５－氟尿嘧啶（５－Ｆｕ）能提高难治性青光眼滤过手术的成功率。为降低结角膜毒性，减少频繁用药，用随机盲法对照实验对５－Ｆｕ不同用药方式进行了比较研究。术中在滤过部位使用高浓度５－Ｆｕ（４０ｍｇ／ｍｌ）比术后用药更能提高手术成功率，临床上未见明显的眼毒副作用。光镜检查术中５－Ｆｕ用药组可见潜在的滤腔。电镜检查两组５－Ｆｕ用药组均可见减少变细、紊乱排列的胶原纤维。

ostoperative subconjunctival injections of fluorouracil(5 Fu)can improve the success of filtration surgery for refractory glaucoma. To reduce corneal toxicity and eliminate the need for frequent administration,an alternative method for application of 5 Fu was investigated.A prospective,randomized,masked observer,placebo controlled study was performed.Intraoperative application of high dose 5 Fu(40mg/ml)to the filtration site can greatly increase surgical success than postoperative subconjective injections.No significant ocular toxicity was observed clinically.Light microscope showed a patenty bleb cavity in intraoperative 5 Fu treated eyes.Attenuated,disordered collagen fibers were found in both 5 Fu treated groups.when tissues were examined by the electron microscope.