远端脾腔静脉分流术对肝硬变门静脉高压症大鼠胃粘膜的影响

Effects of distal splenocaval shunt on gastric mucosa in cirrhotic portal hypertension in rats

观察了肝硬变门静脉高压症大鼠在行远端脾腔静脉分流术（ＤＳＣＳ）后胃粘膜的功能改变。结果显示门静脉高压症时胃窦及底部粘膜血流量（ＧＭＢＦ）、糖蛋白（ＧＰ）及ＰＧＥ２、ＰＧＩ２含量等均显著下降，ＤＳＣＳ术后胃底部粘膜的上述指标均逐渐升高，术后５周时明显高于术前；而胃窦部上述指标在术后初期显著下降，尔后逐渐升高至术前水平，以上结果表明：门静脉高压症时胃粘膜防御能力被削弱，导致粘膜病变的发生。ＤＳＣＳ术后选择性改善了胃底部的微循环及功能，对治疗粘膜病变有一定意义。

The functional changes of the gastric mucosa in hapetic cirrhotic portal hypertension after distal splenocaval shunt (DSCS) were observed in rats. It was found that gastric mucosal blood flow and the levels of glycoprotein and prostaglandins of the gastric corpus and antrum were significantly lower in those rats with hepatic cirrhotic portal hypertension than in those of the control group. After DSCS, these parameters of the gastric corpus were gradually increased and were significantly higher than those before DSCS in the 5th week postoperatively. And these parameters of the gastric antrum were remarkably decreased in the early stage after DSCS and gradually recovered to the preoperative levels. These findings suggest that under hepatic cirrhotic portal hypertension, the defensive capacity of the gastric mucosa was weakened to result in pathological changes and DSCS can selectively improve the microcirculation and the functions of the gastric mucosa of the gastric corpus. So it is recommended that DSCS be employed for the treatment of the lesions of gastric mucosa in case of cirrhotic portal hypertension.