二甲基苯蒽诱导大鼠多发性原发性恶性肿瘤模型的观察

An observation on 7,12 dimethylbenz anthrecene induced model of multiple primary malignant tumors in rats

用皮下注射二甲基苯蒽（ＤＭＢＡ）诱发Ｗｉｓｔａｒ大鼠多发性原发性乳腺癌和纤维肉瘤，并以此建立模型，经２４周后致癌组雌性大鼠７０％发生乳腺癌。其中４５％为多发性原发性乳腺癌；４０％发生皮下纤维肉瘤，３５％在实验期间同时发生乳腺癌和皮下纤维肉瘤。雄性大鼠３３．３％发生皮下纤维肉瘤而未发生乳腺癌。

The models of multiple primary mammary gland carcinoma and fibrous sarcoma induced by hypodermal injection of 7, 12 dimethylbenz anthrecene (DMBA) were established in Wistar rats. Twenty four weeks after the injection, it was observed that 70% of the female rats exhibited mammary gland carcinoma. Among them, 45% were with multiple primary mammary gland carcinoma and 40% with subcutaneous fibrous sarcoma. During the experiment, 35% of the female rats exhibited both kinds of malignant tumors while 33.3% of the male ones exhibited only subcutaneous fibrous sarcoma. The establishment of the model is important for further studies of multiple primary malignant tumors.