斯奇康对反复呼吸道感染患儿血清免疫球蛋白水平的影响

The impact of polysaccharide nucleic acid fraction of bacillus calmette-guerin on the serum immunoglobulin of children suffered from repeated respiratory infection

目的观察斯奇康对反复呼吸道感染（RRI）患儿血清免疫球蛋白水平的影响及临床疗效。方法将158例反复呼吸道感染患儿随机分成2组，对照组74例常规抗感染及对症治疗；斯奇康治疗组84例在常规治疗的基础上，臀部肌注斯奇康注射液。两组患儿在治疗前后均取静脉血2mL，用免疫散射比浊法检测血中IgG、IgA、IgM水平。结果治疗组治疗后RRI发作次数明显减少；患儿血清IgG、IgA、IgM水平提高。结论斯奇康对防治反复呼吸道感染有明显疗效，无严重毒副作用。

Objective To observe the impact of polysaccbaride nucleic acid fraction of bacillus calmette-guerin （13CA3-PSY） on the serum immunoglobulin of children suffered from repeated respiratory infection （RRI）. Methods 158 children suffered from RRI were divided into two groups; the control grop （ n = 74） received the regular anti-infection treatment, the BCG-PSY group （ n = 84） received regular treatment plus injection of BCG-PSY. Every child in two groups was taken 2 mL vein blood before and after treatment to determine IgG, IgA, IgM by immunoturbidimetric assay. Results In BCG-PSY group,reoccurrence of RRI decreased greatly,and serum IgG, IgA, IgM increased after treatment. Conclusion BCG-PSY is an effective drug for RRI, no toxicity or less side effect.